Dr Suchetha Kumari
Professor of Biochemistry at K S Hegde Medical Academy from 2000-current.
Title: Association of Delta desaturase activity and Alpha-1 antitrypsin in women with breast
Biography
Biography: Dr Suchetha Kumari
Abstract
Introduction: Breast cancer is a major cause of death among women all over the world. Alpha-1 antitrypsin (A1AT) is a glycoprotein and an inhibitor of serine proteases (1). Binding of A1AT with polyunsaturated fatty acids like Alpha linolenic acid and oleic acid was recently reported (2). Delta 9 desaturase (D9D), D5D and D6D catalyse the rate limiting steps in the fatty acids conversion. Our aim was to find an association between Alpha-1 antitrypsin levels and delta desaturases activity among breast cancer women and control women.
Materials and methods: 40 breast cancer women and 20 control women were analysed for fatty acids by gas chromatography and alpha 1 antitrypsin by immunoturbidimetric method.
Results: Breast cancer women had A1AT levels between 106-240mg/dl whereas the A1AT levels in control women were between 98-180mg/dl. D5D and D9D-18 activities were significantly higher in cancer cases than in the control subject (P=0.001). No statistical significant correlation was observed in both the groups . But there was negative correlation between A1AT and D9D activity in both the groups.
Discussion: Our data indicate that D5D and D9D activities were higher in the breast cancer women. The underlying mechanism could be the competition between n-3 and n-6 long chain fatty acids for eicosanoid production. To our knowledge it is the first time to show the association of delta desaturase activity and A1AT in breast cancer women and control women. Variation in the A1AT and delta desaturases may provide new insights for diagnostic and therapeutic strategies for breast cancer women and help women from cancer.
References
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2. Harris HR, TworogerSS , Hankinson SE ,Rosner BA. Plasma Leptin Levels and Risk of Breast Cancer in Premenopausal Women. Cancer prevention research 2011; 4(9): 1449-56.
3.Metcalfe LD, Schmitz AA, PelkaJR.Preparation of fatty acid esters from lipids for gas chromatography . Anal Chem 1966; 38(3): 514-15